The remodel of the “central dogma”: a metabolomics interaction perspective
- 9 May 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Metabolomics
- Vol. 17 (5), 1-15
- https://doi.org/10.1007/s11306-021-01800-8
Abstract
Background In 1957, Francis Crick drew a linear diagram on a blackboard. This diagram is often called the “central dogma.” Subsequently, the relationships between different steps of the “central dogma” have been shown to be considerably complex, mostly because of the emerging world of small molecules. It is noteworthy that metabolites can be generated from the diet through gut microbiome metabolism, serve as substrates for epigenetic modifications, destabilize DNA quadruplexes, and follow Lamarckian inheritance. Small molecules were once considered the missing link in the “central dogma”; however, recently they have acquired a central role, and their general perception as downstream products has become reductionist. Metabolomics is a large-scale analysis of metabolites, and this emerging field has been shown to be the closest omics associated with the phenotype and concomitantly, the basis for all omics. Aim of review Herein, we propose a broad updated perspective for the flux of information diagram centered in metabolomics, including the influence of other factors, such as epigenomics, diet, nutrition, and the gut- microbiome. Key scientific concepts of review Metabolites are the beginning and the end of the flux of information.Keywords
This publication has 191 references indexed in Scilit:
- AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net PhosphorylationCell Metabolism, 2013
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent DioxygenasesCancer Cell, 2011
- The Osmolyte TMAO Stabilizes Native RNA Tertiary Structures in the Absence of Mg2+: Evidence for a Large Barrier to Folding from Phosphate DehydrationJournal of Molecular Biology, 2010
- The genetics of ageingNature, 2010
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-HydroxyglutarateCancer Cell, 2010
- TrimethylamineN‐oxide influence on the backbone of proteins: An oligoglycine modelProteins, 2009
- The gut microbiota shapes intestinal immune responses during health and diseaseNature Reviews Immunology, 2009
- A core gut microbiome in obese and lean twinsNature, 2008
- Molecular basis for chemoprevention by sulforaphane: a comprehensive reviewCellular and Molecular Life Sciences, 2007
- A top‐down systems biology view of microbiome‐mammalian metabolic interactions in a mouse modelMolecular Systems Biology, 2007