Ocular manifestations of RT-PCR-confirmed COVID-19 cases in a large database cross-sectional study
Open Access
- 22 September 2021
- journal article
- research article
- Published by BMJ in BMJ Open Ophthalmology
- Vol. 6 (1), e000775
- https://doi.org/10.1136/bmjophth-2021-000775
Abstract
Objective To evaluate ocular manifestations of reverse transcriptase (RT)-PCR-confirmed SARS-CoV-2-infected patients in a validated comparative model, and additionally to evaluate the correlation between severity of COVID-19 and ocular manifestations. Methods and Analysis In a prospective cross-sectional study, a total of 2400 subjects were enrolled over a period of 8 months. To eliminate bias of identical ocular symptom profile in other non-COVID-19 respiratory infections and to acquire a comparative model, 1200 COVID-19 RT-PCR-positive patients (group 1) and 1200 RT-PCR-negative patients (group 2) were included. Data collection included use of a prestructured tool and ‘Google-forms’, along with stratification of patients into ‘mild, moderate, and severe’ categories. Study subjects were evaluated for ocular manifestations by clinical examination and laboratory work-up. Univariate and multivariate logistic regression analyses were performed. Results 144 (12%) patients in group 1 had ocular symptoms as compared with 24 (2%) patients in group 2 (pConclusion The frequency of occurrence of ocular manifestations was higher in group 1 as opposed to group 2. Furthermore, the presence of ocular manifestations carried a direct correlation with severity of systemic disease and presence of comorbidities.This publication has 32 references indexed in Scilit:
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