Highly Regio‐, Diastereo‐, and Enantioselective Synthesis of Tetrahydroazepines and Benzo[b]oxepines through Palladium‐Catalyzed [4+3] Cycloaddition Reactions
- 14 October 2019
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 59 (3), 1243-1247
- https://doi.org/10.1002/anie.201911537
Abstract
A novel Pd(0)‐catalyzed asymmetric [4+3] annulation reaction of two readily accessible starting materials has been developed for building seven‐membered heterocyclic architectures. The potential [3+2] side pathway could be suppressed though fine tuning of the conditions. A broad scope of cycloaddition donors and acceptors participated in the transformation with excellent chemo‐, regio‐, diastereo‐ and enantioselectivtities, leading to valuable tetrahydroazepines and benzo[b]oxepines.This publication has 55 references indexed in Scilit:
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