One-pot multi-component synthesis of tetrahydroquinazolinones via Biginelli condensation using molecular iodine as a catalyst
Open Access
- 31 December 2013
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 4 (4), 459-461
- https://doi.org/10.5155/eurjchem.4.4.459-461.821
Abstract
Tetrahydroquinazolinone derivatives were synthesized in moderate to high yields via one‐pot three component Biginelli reaction of dimedone, urea or thiourea and corresponding aromatic aldehydes in the presence of molecular iodine as an efficient catalyst, in ethanol under reflux conditions. This protocol offers several advantages including good yields of products and easy experimental work‐up procedure.Keywords
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