Endothelial Repair and Endothelial Cell-Derived Secretome
Open Access
- 9 January 2017
- journal article
- Published by Heighten Science Publications Corporation in Insights in Biology and Medicine
- Vol. 1 (1), 001-008
- https://doi.org/10.29328/journal.hjbm.1001001
Abstract
Growing evidence supports the hypothesis that endothelial cell-derived microparticles (MPs) might contribute to the pathogenesis of cardiovascular (CV) disease. Endothelial cell-derived MPs play a pivotal role in the regulation of the endogenous repair system, thrombosis, coagulation, inflammation, immunity and metabolic memory phenomenon. There is evidence that the MPs are secreted actively accompanied to other regulatory molecules. All these actively synthetizing and secreting factors include proteins, adhesion and intercellular signal molecules, peptides, lipids, free DNAs, microRNAs, and even microparticles (MPs) are defined as cellular secretome. The proteomic profile of secretome is under tightly control of genetic and epigenetic mechanisms, which may altered a secretion of the proteins involved into MPs’ organization. Finally, this may contribute the modification of MP’s after their secretion and throughout transfer to the target cells. As a result, communicative ability of endothelial cell-derived MPs may sufficiently worse. Subsequently, cross talk between some components of secretome might modulate delivering cargos of MPs and their regenerative and proliferative capabilities via intercellular signaling networks. The aim of the review is to discuss the effect of various components of secretome on MP-dependent effects on endothelium.Keywords
This publication has 49 references indexed in Scilit:
- Anti-Thymocyte Globulin Induces Neoangiogenesis and Preserves Cardiac Function after Experimental Myocardial InfarctionPLOS ONE, 2012
- Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular DiseaseCell Stem Cell, 2012
- Impact of glycemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitusCardiovascular Diabetology, 2011
- Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical studyBasic Research in Cardiology, 2011
- Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarctionBasic Research in Cardiology, 2011
- MicroparticlesCirculation Research, 2010
- Exosomes: Extracellular organelles important in intercellular communicationJournal of Proteomics, 2010
- Use of SYTO 13, a fluorescent dye binding nucleic acids, for the detection of microparticles in in vitro systemsCytometry Part A, 2010
- Activation of Akt/GSK-3β signaling pathway is involved in intermedin1–53 protection against myocardial apoptosis induced by ischemia/reperfusionApoptosis, 2009
- Proteomics, Metabolomics, and Immunomics on Microparticles Derived From Human Atherosclerotic PlaquesCirculation: Cardiovascular Genetics, 2009