A type 2 diabetes mellitus patient was successfully treated by autologous bone marrow-derived stem cell transplantation: A case report
Open Access
- 4 January 2019
- journal article
- research article
- Published by Biomedical Research and Therapy in Biomedical Research and Therapy
- Vol. 6 (1), 2966-2969
- https://doi.org/10.15419/bmrat.v6i1.516
Abstract
Introduction: Type 2 diabetes mellitus (T2DM) iscurrently one of the most common diseases as a result of obesity and aging. Currently, T2DMis treated by various methods, such as insulin injection and glucose regulation agents. In this report, we report the case of a T2DM patient who was successfully treated by autologous bone marrow-derived stem cell transplantation. Methods: The patient was diagnosed with T2DM by standard methods for more than ten years. The patient agreed to be treated by the new approach – autologous bone marrow-derived stem cell transplantation. The bone marrow was collected from the patient twice at 100 mL volume each time. The stem cellenriched mononuclear cells (MNCs) in the bone marrow were isolated by gradient centrifugation. MNCs were intravenously transfused into the patient twice within the 1-month interval. The lasting glucose and 2h-after meal glucose, as well as hemoglobin A1c (Hab1c), were recorded before transplantation, and 1-, 3-, and 6-months post-transplantation. Results: The results showed that there were no adverse effect recorded during the monitoring period, and that the T2DM symptoms significantly improved. After the first round of transplantation, the glucose level reduced considerably and continued to decrease out to 3 months. Meanwhile, after 2 months of transplantation, the Hab1C level decreased and achieved the average level at the 3rd month of treatment. After 6 months, the patient was free from insulin injection and maintained glucose and Hab1c level. To date, after 9 months of treatment; the patients has continued to be free from insulin injection and without any adverse effects. Conclusion: The primary results have suggested that autologous bone marrow-derived stem cell transplantation may be a new direction for T2DM treatment.Keywords
This publication has 18 references indexed in Scilit:
- Bone-marrow-derived very small embryonic-like stem cells in patients with critical leg ischaemia: evidence of vasculogenic potentialThrombosis and Haemostasis, 2015
- Cellular Senescence in Type 2 Diabetes: A Therapeutic OpportunityDiabetes, 2015
- Mesenchymal Stem Cells Derived from Human Bone MarrowMethods in Molecular Biology, 2015
- Prevalence of diabetes complications in people with type 2 diabetes mellitus and its association with baseline characteristics in the multinational A1chieve studyDiabetology & Metabolic Syndrome, 2013
- Insulin Resistance and Type 2 DiabetesDiabetes, 2012
- Bone Marrow-Derived Endothelial Progenitor Cells: Isolation and Characterization for Myocardial RepairMethods in molecular biology (Clifton, N.J.), 2010
- Isolation of Human and Mouse Hematopoietic Stem CellsMethods in molecular biology (Clifton, N.J.), 2009
- Type 2 Diabetes Mellitus and Skeletal Muscle Metabolic FunctionPhysiology & Behavior, 2008
- Insulin Resistance, Type 2 Diabetes Mellitus, and Cardiovascular DiseaseJournal of the American College of Cardiology, 2005
- Gene expression profile of cytokine and growth factor during differentiation of bone marrow-derived mesenchymal stem cellCytokine, 2005