A hydrophobic antifouling surface coating on bioprosthetic heart valves for enhanced antithrombogenicity
- 1 December 2021
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Vol. 110 (5), 1082-1092
- https://doi.org/10.1002/jbm.b.34982
Abstract
Thrombosis is an important factor that causes the failure of artificial biological valves in addition to calcification and immune rejection. A hydrophobic antifouling surface can improve blood compatibility by reducing the absorption of protein. In this study, porcine pericardium was cross-linked with glycidyl methacrylate, and carbon–carbon double bonds were introduced. Then, fluoride monomer was added so that the pericardial surface would become hydrophobic and antifouling. Fluoride modification changed the hydrophilicity of the pericardium surface, and the surface water contact angle increased from 84° to 143°. Compared with unmodified pericardium, the adsorption of bovine serum albumin and fibrinogen decreased by 93.1% and 85%, respectively, and the anti-thrombogenicity was greatly enhanced.Keywords
This publication has 32 references indexed in Scilit:
- Bioinspired self-repairing slippery surfaces with pressure-stable omniphobicityNature, 2011
- Polymer Brushes Showing Non‐Fouling in Blood Plasma Challenge the Currently Accepted Design of Protein Resistant SurfacesMacromolecular Rapid Communications, 2011
- Surface free energy of polypropylene and polycarbonate solidifying at different solid surfacesApplied Surface Science, 2009
- Superhydrophobic surfacesCurrent Opinion in Colloid & Interface Science, 2006
- Hydrophobicity and Sliding Behavior of Liquid Droplets on the Fluorinated Latex FilmsMacromolecules, 2005
- Mediation of Biomaterial–Cell Interactions by Adsorbed Proteins: A ReviewTissue Engineering, 2005
- Low Free Energy Surfaces Using Blends of Fluorinated Acrylic Copolymer and Hydrocarbon Acrylic Copolymer LatexesMacromolecules, 2000
- The Lowest Surface Free Energy Based on −CF3 AlignmentLangmuir, 1999
- Estimation of the surface free energy of polymersJournal of Applied Polymer Science, 1969
- III. An essay on the cohesion of fluidsPhilosophical Transactions of the Royal Society of London, 1805