Catalyst-free, one-pot strategy to access 3-substituted-5-amino-1,2,4-thiadiazoles in water
- 11 October 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in Synthetic Communications
- Vol. 51 (23), 3610-3619
- https://doi.org/10.1080/00397911.2021.1986840
Abstract
A protocol has been devised for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles utilizing isothiocyanates, amidoximes and water as an eco-friendly solvent. The strategy involves consecutive C−N and S−N bonds formation in a one-pot reaction under catalyst-free conditions. Operational simplicity, low cost, broad substrate scope and readily available starting materials are the main features of this protocol. Graphical AbstractKeywords
Funding Information
- UGC (BT/PR23078/MED/29/1253/2017)
- VGST (KSTePS/VGST/K-FIST(L1)/2017-18/GRD-681/79/2018-2019)
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