Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties
- 11 January 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 143 (3), 1278-1283
- https://doi.org/10.1021/jacs.0c11641
Abstract
Deferasirox, ExJade, is an FDA-approved iron chelator used for the treatment of iron overload. In this work, we report several fluorescent deferasirox derivatives that display unique photophysical properties, i.e., aggregation-induced emission (AIE), excited state intramolecular proton transfer, charge transfer, and through-bond and through-space conjugation characteristics in aqueous media. Functionalization of the phenol units on the deferasirox scaffold afforded the fluorescent responsive pro-chelator ExPhos, which enabled the detection of the disease-based biomarker alkaline phosphatase (ALP). The diagnostic potential of these deferasirox derivatives was supported by bacterial biofilm studies.Funding Information
- Welch Foundation (F-0018)
- Ministry of Education of the People's Republic of China (222201717003)
- Science and Technology Commission of Shanghai Municipality (17520750100)
- National Natural Science Foundation of China (21722801, 21788102, 31871414, 81673489, 91853201)
- National Institute of General Medical Sciences (R01 GM103790)
- Shanghai Municipality (2018SHZDZX03)
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