Abstract: The paper establishes the relationship between enzymatic activity and the proliferation of hepatocytes. Low-intensity physical activity is shown not to influence the activity of hepatocytes’ enzymes and their proliferation. Hard work results in decreased activity of redox enzymes; at the same time, the proliferation of hepatocytes is inhibited for a long time. The most favorable is moderate load, which leads to the activation of oxidative-reducing enzymes and increases the number of binucleated hepatocytes, which persist for a long time after the end of the experiment.