| Lumpy Skin Disease (LSD ) is an economically important transboundary viral disease of livestock belonging to the genus Capripoxvirus was reported which was said to have originated from Zambia in Africa. LSD can be transmitted by both the vector and non-vector routes and is mainly seen in the rainy season. It mainly affects cattle and buffalo manifesting nodules in skin and mucous membrane with a high fever. Since the first report of this disease from the Morang district of Nepal in 2020, the disease has been spreading in various parts of the country. Cattle are comparatively more affected in Nepal than buffalo. Though this disease has less mortality rate it causes great economic losses by decreasing milk production, abortion, infertility, and other complication. The disease is comparatively new to Nepal but has already covered a wide geographical range but vaccination is yet to be introduced. The disease doesn’t have any specific treatment only treatment after infection is supportive therapy but it is reported that control and prevention are possible by immunization, maintaining biosecurity in the herd, controlling the vector, and isolating the infected animals.