A COMPARATIVE STUDY OF CENTCHROMAN AND DANAZOL IN MANAGEMENT OF MASTALGIA.

Abstract

Mastalgia is one of the most common presenting symptom in female attending surgical and gynaecological OPD. In majority of patients it can be managed with reassurance and simple medication. But in 10-20 % of patient severe pain affects quality of life and causes severe anxiety. Aim was to compare the effectiveness of Centchroman and Danazol in mastalgia by using visual analogue scale (VAS), Fifty-two patients were taken in study & randomized into two groups with all women presenting with mastalgia with VAS score ≥3 between ages of 20-40 years. Centchroman (30mg OD for 3 months) in group 1 and Danazol (50 mg bid for 3 months) to group 2 was given and were monitored for VAS for pain and we found that centchroman is more effective than danazol and there was signicant difference in parameters in both the groups as Age, VAS th score, duration of menstrual cycle, No. of cases with cyclical, non-cyclical mastalgia. Relative risk (RR) of 1.256 at 12 week, 2.280 at th 24 week were noted, P value was found to be signicant. It can be concluded that Centchroman therapy is a safe, equally effective, and less costly alternative to Danazol for the treatment of mastalgia.