This study was established during 2017 and 2018 seasons to test the effect of single and combined applications of fish oil and glutathione each at 0.5 to 2% on some vegetative growth aspects, photosynthetic pigments, flowering and fruit setting behavior, N, P, K, Mg, Ca (as %), Zn, Fe, Mn and Cu (as ppm), yield and both physical and chemical characteristics of the fruits in mango cv. Ewaise grown under sandy soil. The trees received three sprays at growth start, just after fruit setting and at 30 days later. Single and combined applications of fish oil and glutathione each at 0.5 to 2% had substantial promotion on shoot length and thickness, number of leaves/shoot, leaf area (in the spring growth cycle), photosynthetic pigments (chlorophylls a & b, total chlorophylls and total carotenoids), N, P, K, Mg, Ca (as %), Zn, Fe, Mn and Cu (as ppm), panicle length, number of panicles/tree, perfect flowers %, percentages of initial and fruit retention, yield and fruit quality characteristics over the control. Using glutathione was reasonably superior than using fish oil in enhancing all the studied parameters. Companied applications were materially favourable than using each material alone. In all cases negligible effect was observed on these parameters among the higher two concentrations of each material (1 & 2%). The best results with regard to growth, tree, nutritional status, flowering, fruit setting, yield and fruit quality were obtained due to treating Ewaise mango trees grown under sandy soil thrice (growth start, just after setting and at one month later) with a mixture of fish oil and glutathione each at 1%.