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Irakli Chkhikvishvili, David Chkhikvishvili, Nunu Gogia, Maya Enukidze, Marine Machavariani, Nana Kipiani, Eka Shekhiladze, Tamar Sanikidze

Abstract: Cancer plays a leading role in increased morbidity and mortality in the world. In recent years, special attention has been paid to the use of natural medicines among the new effective methods of cancer treatment. Paclitaxel can be isolated from the hazelnut’s (Corylus avellana L.) shells and leaves. Taxane-polyphenols synergism is known to enhance the efficacy and selectivity of chemotherapeutic drugs. Therefore, screening of taxane-polyphenol combinations is needed to select a highly effective complex. The aim of the study was to study the effectiveness of different polyphenol substitute fractions obtained from hazelnut residue extraction on tumor cell viability in Jurkat cell model systems. Studies were performed on human leukemia transformed mature T-cells (Jurkat cells) (DSMZ-Deutshe Sammulung von Mikroorganismen und Zell kulturen (Germany)). Extraction of compounds from the nut residue (hard shell) was carried out using solvents, chloroform, ethyl acetate, methanol and ethanol (Sigma-Aldrich). Chromatographic separation was performed on a high-pressure liquid chromatograph Agilent 1260 Infinity (USA).Based on the analysis of the research results, we can conclude that the ethanol extract of hazelnut shells which is characterized by a small content of paclitaxel, but a high content of polyphenols, is characterized by most high cytotoxicity against Jurkat cells.
Keywords: EFFICACY / VIABILITY / polyphenols / hazelnut / treatment / model / Jurkat cells / TAXANE POLYPHENOL

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