Plant immune systems rely on their ability to recognize enemy molecules, carry out signal transduction, and respond defensively through pathways involving many genes and their products. This Perspective paper aims to explore current views on the vaccination (immunization) of plants against diseases caused by microorganisms and their (macro)molecular components, paying special attention to practical applications. We conclude that the technique of vaccination to control plant disease needs to be further investigated, developed, and considered for wider implementation in plant protection practice.