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Study Correlation between Some Immune Markers in Patients with Lichen Planus: Review Article

Nagham H. Ali, Amir A. Majeed
International Journal for Research in Applied Sciences and Biotechnology , Volume 8, pp 38-44; doi:10.31033/ijrasb.8.2.5

Abstract: Lichen planus is an autoimmune disorder that primarily affects the body's skin and multiple mucous membranes. In multicellular species, protein 53 and syndecan-1protein play an significant role since they control the cell cycle and thus play a major role in tumor suppression and cancer prevention. The p53 gene was therefore identified as a "genome protector," referring to its role in preserving the integrity of genetic information by preventing gene mutations. The purpose of this analysis was to study the association between certain immune markers in lichen planus patients. The aim of this study: Study correlation between some immune markers in patients with lichen planus. Methods: 'Thirty formalin-fixed, paraffin-embedded tissue pieces, diagnosed as Oral Lichen planus (OLP), were included in the sample of this report. Results: Evaluation of P53 Immunohistochemistry and Evaluation of syndecan-1protein Immunohistochemistry Conclusion: The marker p53 expression is high in the patient with Lichen Planus while the second studed markersyndecan-1 protein is less than marker p53.
Keywords: immune markers / Immunohistochemistry / lichen planus patients / syndecan 1protein

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