Positive effects of renal denervation on markers of cardiovascular inflammation and left ventricular mass. 24-months follow-up
Open Access
- 28 March 2021
- journal article
- Published by Silicea - Poligraf, LLC in Cardiovascular Therapy and Prevention
- Vol. 20 (2), 2678
- https://doi.org/10.15829/1728-8800-2021-2678
Abstract
Aim. To study the long-term effect of renal denervation (RDN) on left ventricular mass (LVM) and inflammatory markers in resistant hypertensive patients.Material and methods. Forty-one patients with resistant hypertension and 24-h blood pressure (BP) 158,7±15,8/87,3+14,6 mmHg, aged 56,6+10,2 years, were enrolled in the study and undergone RDN. Mean 24-h BP, left ventricular mass (transthoracic echocardiography), high sensitivity C-reactive protein (hsCRP), interleukin- 1β (IL1β), IL-6, IL-10) and tumor necrosis factor alpha (TNF- α) were assessed at baseline and 2 years after the RDN.Results. A baseline prevalence of left ventricular hypertrophy (LVH) was 90,2%. Two years after RDN LVM and interventricular septum (IVS) decreased significantly (p0 g) was documented in 24 patients. The regression of LVM was accompanied by a significant decrease in levels of inflammatory markers — hsCRP by 38,3% (p=0,031), TNF-α by 60,7% (p=0,009), IL- 1β — by 71,1% (p=0,001), and IL-10 by 58,2% (p=0,001). In patients in the absence of LVM regression only TNF-α decreased significantly (-68,8%, p=0,001). There was no correlation between changes of LVM and the inflammatory markers at 24 months after RDN.Conclusion. The RDN in RH patients may have long-term cardioprotective effect in terms of significant regress of LVH, which may be partly attributed to the regress in systemic or myocardial inflammation.Keywords
This publication has 15 references indexed in Scilit:
- Positive effects of renal denervation on left ventricular hypertrophy and subendocardial damage"Arterial’naya Gipertenziya" ("Arterial Hypertension"), 2019
- Reductions of left ventricular mass and atrial size following renal denervation: a meta-analysisClinical Research in Cardiology, 2016
- Long-term effects of multielectrode renal denervation on cardiac adaptations in resistant hypertensive patients with left ventricular hypertrophyJournal of Human Hypertension, 2016
- Roles of Inflammation, Oxidative Stress, and Vascular Dysfunction in HypertensionBioMed Research International, 2014
- Resistant hypertension and left ventricular hypertrophy: an overviewJournal of the American Society of Hypertension, 2010
- Blood pressure reduction, persistence and costs in the evaluation of antihypertensive drug treatment – a reviewCardiovascular Diabetology, 2009
- Left Atrial Size and Risk of Major Cardiovascular Events During Antihypertensive TreatmentHypertension, 2007
- Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within five years. The Cardiovascular Health StudyACC Current Journal Review, 2004
- Increased size of myocardial infarction in dogs with chronic hypertension and left ventricular hypertrophy.Circulation Research, 1982
- Blood pressure and survival after myocardial infarction: The Framingham studyThe American Journal of Cardiology, 1980