The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study
- 13 March 2017
- journal article
- research article
- Published by Taylor & Francis Ltd in Endocrine Research
- Vol. 42 (3), 1-7
- https://doi.org/10.1080/07435800.2017.1292523
Abstract
The adipocytokines and insulin-like growth factor 1 (IGF-1) are involved in insulin resistance, the cardiometabolic syndrome, and atherosclerosis. Therefore, investigating the relationship between circulating levels of the novel adipocytokines and IGF-1 is worthwhile. The correlation between IGF-1, visfatin, and omentin-1 has not been adequately investigated. In a population-based study, 324 postmenopausal women were randomly selected. Circulating IGF-1, visfatin, omentin-1, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) levels were measured with the highly specific enzyme-linked immunosorbent assay method. In multiple regression analyses adjusted for alkaline phosphatase, osteocalcin, and hs-CRP, circulating IGF-1 was significantly correlated with visfatin levels (standardized β coefficient [β] = 0.13, partial correlation coefficient [r] = 0.12, p = 0.028). The significant positive correlation between serum IGF-1 and visfatin levels remained after additional adjustments for age and BMI (β = 0.12, r = 0.12, p = 0.025), metabolic syndrome (β = 0.13, r = 0.12, p = 0.021), and type 2 diabetes mellitus (β = 0.13, r = 0.12, p = 0.026). No significant correlations were found between IGF-1, adiponectin, and omentin-1. There is a significant correlation between serum IGF-1 and visfatin levels in postmenopausal women beyond metabolic syndrome, type 2 diabetes, bone formation markers, and hs-CRP levels. The observed correlation between higher circulating IGF-1 and the higher visfatin levels might be a physiological compensation and adaptation to protect against visfatin-induced proinflammatory effects.Keywords
Funding Information
- Bushehr University of Medical Sciences and Health Services and Bushehr Province Research Committee (1385.234.345)
This publication has 36 references indexed in Scilit:
- Visfatin/Nampt: An Adipokine with Cardiovascular ImpactMediators of Inflammation, 2013
- Advances in adipokinesMetabolism, 2012
- Role of adipokines in cardiovascular diseaseJournal of Endocrinology, 2012
- Omentin-1 is associated with carotid atherosclerosis in patients with metabolic syndromeDiabetes Research and Clinical Practice, 2011
- Omentin: A Novel Link Between Inflammation, Diabesity, and Cardiovascular DiseaseTrends in Cardiovascular Medicine, 2010
- Adiponectin action from head to toeEndocrine, 2009
- Omentin Plasma Levels and Gene Expression Are Decreased in ObesityDiabetes, 2007
- Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin actionAmerican Journal of Physiology-Endocrinology and Metabolism, 2006
- Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesityProceedings of the National Academy of Sciences of the United States of America, 2005
- Early Metabolic Defects in Persons at Increased Risk for Non-Insulin-Dependent Diabetes MellitusThe New England Journal of Medicine, 1989