Aims: Osteoarthritis, the most common form of arthritis which commonly affects weight-bearing joints like the knee, hip, spine, and joints. Since the effectiveness of conventional medicine on severe types of osteoarthritis is surgical intervention, the patients are seeking alternative medicine. A warm Epsom salt pack is used commonly for pains over joints. Hence this study is undertaken. Study Design: Randomized Controlled Trial. Place and Duration of Study: Department of Naturopathy, SDM College of Naturopathy and Yogic Sciences, between November 2019 and January2020. Methodology: From the inpatient department of Shri Dharmasthala Yoga and Nature cure Hospital Shanthivana, hundred subjects diagnosed with osteoarthritis belonging to the age groupof35to75yearswererecruitedandwererandomlyallocated to case (Warm Epsom salt pack) and control group. Subjects were assessed for Goniometry, Visual analog scale (VAS), Shortform-12(SF-12), Western Ontario and McMaster Osteoarthritis Index Scale (WOMAC) before and after the intervention of 20 minutes. Results: The study was done to evaluate the effect of Warm Epsom salt on Knee Osteoarthritis. There were 100 subjects in the sample. Shapiro-Wilk’s test/Quantile-Quantile (QQ) plot was used to check the normality of variables. In study group there was a significant decrease in Goniometry (p=<0.0001), SF 12 (p=<0.0001), WOMAC (P=<0.0001). In the control group, other than VAS there were no significant changes in other variables (Goniometry, WOMAC, SF-12). Conclusion: Our study indicates that a warm Epsom salt pack may reduce pain, stiffness, range of motion, and improves the quality of life. The study revealed that Warm Epsom salt reduced Range of motion from 172.94 to 134.5, WOMAC from 65.94 to 26.38, and Quality of life from 33.98 to 31.22. Results reveal with significant improvement (p<0.001) in pain, swelling, and quality of life.