Immunoscreening of Alpha-Tocopherol in Breast, Prostate Cancers and in Gestational Choriocarcinoma Tissues
Open Access
- 1 January 2021
- journal article
- Published by Scientific Research Publishing, Inc. in CellBio
- Vol. 10 (02), 11-21
- https://doi.org/10.4236/cellbio.2021.102002
Abstract
Background: Many literature reviews report vitamin E supplementation as a benefit chemopreventive and adjuvant therapy in breast and prostate cancers. We investigated in the present work, alpha-tocopherol (α-T) expression (the current active form of vitamin E) from tissues of Congolese patients neither smokers nor alcohol drinkers and without intake antioxidant vitamins supplement. Methods: α-T was analysed in one normal placenta of nine weeks of gestation and in nineteen cancerous tissues, including seven breast cancers, six prostate cancers, and six gestational choriocarcinomas. The study was performed by immunohistochemistry method after diagnosis confirmation by histological analysis. Results: α-T staining in membrane cells and collagen fibers presented a moderate expression in healthy sections of tissues (positive control), but the labelling was strong in breast, prostate adenocarcinomas, and in choriocarcinomas. Conclusion: Tumors immunohistochemistry of α-tocopherol in breast, prostate cancers and in choriocarcinoma show elevated immunostaining suggesting a probable oncogenic effect of the micronutrient.Keywords
This publication has 32 references indexed in Scilit:
- Dietary Administration of δ- and γ-Tocopherol Inhibits Tumorigenesis in the Animal Model of Estrogen Receptor–Positive, but not HER-2 Breast CancerCancer Prevention Research, 2012
- Nutrition and physical activity guidelines for cancer survivorsCA: A Cancer Journal for Clinicians, 2012
- Oxidative stress stimulates α-tocopherol transfer protein in human trophoblast tumor cells BeWojpme, 2012
- Chemopreventive Activity of Vitamin E in Breast Cancer: A Focus on γ- and δ-TocopherolNutrients, 2011
- Vitamin Supplement Use During Breast Cancer Treatment and Survival: A Prospective Cohort StudyCancer Epidemiology, Biomarkers & Prevention, 2011
- Frontiers in Vitamin Research: New Antibodies, New DataThe Scientific World Journal, 2011
- Selenium and Vitamin E: Cell Type– and Intervention-Specific Tissue Effects in Prostate CancerJNCI Journal of the National Cancer Institute, 2009
- Detrimental effects of high levels of antioxidant vitamins C and E on placental function: Considerations for the Vitamins in Preeclampsia (VIP) trialJournal of Obstetrics and Gynaecology Research, 2008
- Serum and Dietary Vitamin E in Relation to Prostate Cancer RiskCancer Epidemiology, Biomarkers & Prevention, 2007
- Prostate Cancer and Supplementation With α-Tocopherol and β-Carotene: Incidence and Mortality in a Controlled TrialJNCI Journal of the National Cancer Institute, 1998