An observational study of cutaneous manifestations in patients on chemo and radiation therapy for internal malignancies at Tertiary Care Center
Open Access
- 31 October 2022
- journal article
- research article
- Published by Medknow in Indian Dermatology Online Journal
- Vol. 13 (6), 757-764
- https://doi.org/10.4103/idoj.idoj_168_22
Abstract
Context: Chemotherapy and radiation therapy given to treat internal malignancies may cause cutaneous, hair, nail, and oral mucosal changes. The present study is an effort to know the pattern of cutaneous drug reactions with chemo and radiotherapy. Materials and Methods: Patients of internal malignancies with skin lesions attending the dermatology and oncology OPD/ward were recruited after taking their written consent in vernacular language. A detailed history of skin lesions, malignancies, and treatment was taken. Clinical examination was carried out. Relevant investigations and biopsy were carried out as and when required. Being a descriptive study, age group and gender-wise frequency and percentage were calculated for the treatment of malignancies and dermatosis. Results: The study included 150 patients with 28 different types of internal malignancies, of which 127 (84.66%) patients were treated, 45 (35.43%) treated exclusively with chemotherapy, 16 (12.59%) with exclusive radiation therapy, and 66 (51.96%) with combined chemo and radiation therapy. Total 111 (87.41%) patients received chemotherapy and 82 (64.56%) patients received radiation therapy. Most common internal malignancy was breast carcinoma in 43 (28.67%) cases. Most common chemotherapeutic agent given was paclitaxel to 33 (29.73%) patients. Most common dermatosis associated with exclusive chemotherapy was hand-foot syndrome in 7 (15.55%) cases and with exclusive radiation therapy was radiation dermatitis in 8 (50%) cases. Conclusions: The study was useful in understanding various chemo and radiation therapy-associated dermatosis so that early interventions can be done to prevent further treatment-related adverse effects. Limitation: Small sample size and inability of pinpointing a single drug as the side effect.Keywords
This publication has 16 references indexed in Scilit:
- Radiodermatitis: A Review of Our Current UnderstandingAmerican Journal of Clinical Dermatology, 2016
- Dermatological adverse reactions to cancer chemotherapyIndian Journal of Dermatology, Venereology and Leprology, 2015
- Chemotherapy or Radiation-Induced Oral MucositisDental Clinics of North America, 2014
- Anagen effluviumIndian Journal of Dermatology, Venereology and Leprology, 2013
- MelanonychiaDermatology Research and Practice, 2012
- Chemotherapy and skin reactionsJournal of Experimental & Clinical Cancer Research, 2012
- Cancer and Radiation Therapy: Current Advances and Future DirectionsInternational Journal of Medical Sciences, 2012
- Effects of epidermal growth factor receptor inhibitor‐induced dermatologic toxicities on quality of lifeCancer, 2010
- Toxic effects of multiple anticancer drugs on skin.2010
- Malignancy and Cancer Treatment-Related Hair and Nail ChangesDermatologic Clinics, 2008