This study was aimed at assessing the readiness for drug information service (DIS) provision at community pharmacies in Akwa Ibom state using a cross sectional, observational study approach. A pretested, validated questionnaire was adapted for the study. A total of 187 premises were enlisted for visits with questionnaires targeted at the superintendent pharmacists for desired responses. Response rate was 93.6%. Respondents were male (77, 44%) and female (98, 56%) with mean years of experience of respondents as 18.7 years. All respondents were aware of DIS terminologies and believed the concept to include enquiries on dosing (75%), side effects of drugs (99%), safety of drugs in cases such as pregnancy (79%), drug route of administration (80%), pill identification (66%) and substitutes to requested drugs (78%). Responses to limitations in discharging efficient DIS include non-trending service style (26%), premises requiring restructuring (26%), prohibitive setting up cost (17%) and non-availability of trained personnel (7%). At the time of this study, available resources for DIS in the premises included reference books (90%), periodicals (19%), and internet access through smart phones (60%). Secondary and tertiary sources of drug information were essentially relied on for DIS provision in the study area. There was significant association between socio-demographic characteristics such as age with readiness status (p 0.05) in the DIS approach across the state. There is need for improvement in facilities and resources for efficient discharge of DIS in the study area.