Atopic dermatitis (AD), also called atopic eczema, is a common chronic or recurrent inflammatory skin disease and affects 15–20% of children and 1–3% of adults worldwide; IgE is likely to be of more relevance in pediatric disease than in adult disease, in order to detect the incidence of AD and its association with elevated total serum IgE level, 68 people were involved in the current study, their ages were (1-45) years and from both genders fifty of them was with atopic dermatitis and the other healthy eighteen were considered as control groups. They are all subjected to the estimation of total serum IgE level by using Nephelometry methodology technique in the central health laboratory and Hilla Teaching Hospital the period Nov. 2017 to Feb. 201in Babylon Governorate. A significant increase in the level of IgE in AD patients was detected in all age groups in comparison with the control group. The results also showed that patients of blood group (o+) are the most frequent by percent (28%) followed by B+, AB+, A+ and AB¯ with percent reached (24, 20, 14and 4%) respectively. Furthermore, there is a genetic tendency in the frequency of onset of AD as 10% in both parents and (30& 24%) in mothers and fathers respectively while 36% of the disease does not appear in their families. Results also showed a significant increase in the age groups (31-45) years in comparison with (1-15) and (16-30) years. The disease also rises in males compared with females. A significant increase in IgE for patients with Atopic Dermatitis