Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study
Open Access
- 9 May 2023
- journal article
- research article
- Published by BMJ in BMJ Paediatrics Open
- Vol. 7 (1), e001853
- https://doi.org/10.1136/bmjpo-2023-001853
Abstract
Purpose Germinal matrix haemorrhage/intraventricular haemorrhage (GMH-IVH) is a multifactorial injury with both anatomic and haemodynamic involvement. Normal variants in preterm deep cerebral venous anatomy associated with GMH-IVH have been previously described using MRI susceptibility weighted imaging (SWI). The aims of this study were to use SWI to compare the deep venous systems of a cohort of preterm neonates with various grades of GMH-IVH to a group of age-matched controls without GMH-IVH and to present novel retrospective SWI imaging findings. Methods A neuroradiologist retrospectively evaluated 3T MRI SWI and phase imaging of 56 preterm neonates with GMH-IVH (14 of each grade) and 27 controls without GMH-IVH, scoring the venous irregularities according to three variables: decreased venous patency, increased lumen susceptibility and the presence of collaterals. Eight different venous locations, including indicated bilateral components, were evaluated: straight sinus, vein of galen, internal cerebral, direct lateral, thalamostriate, atrial and the anterior septal veins. Variables were analysed for statistical significance. Inter-rater reliability was determined via subset evaluation by a second paediatric radiologist. Results Deep venous abnormalities were significantly more common in patients with GMH-IVH, with Wilcoxon Rank Sum Test demonstrating significant increase with GMH-IVH for total decreased venous patency (W=0, pConclusion Deep venous abnormalities are significantly correlated with GMH-IVH alone and an increase in GMH-IVH grade. Further study is needed to determine cause and effect.Funding Information
- National Heart, Lung, and Blood Institute (T35HL007489)
- National Institutes of Health (R01HD105055-01A1)
This publication has 38 references indexed in Scilit:
- Different gestational ages and changing vulnerability of the premature brainThe Journal of Maternal-Fetal & Neonatal Medicine, 2013
- The premature brain: developmental and lesional anatomyNeuroradiology, 2013
- The blood–brain barrier: an overview: Structure, regulation, and clinical implicationsNeurobiology of Disease, 2004
- The Weismann-Netter, Stuhl syndrome: A rare pediatric skeletal dysplasiaPediatric Radiology, 1995
- Developmental change in type VI collagen in human cerebral vesselsPediatric Neurology, 1992
- Seizures in the preterm infant: Effects on cerebral blood flow velocity, intracranial pressure, and arterial blood pressureThe Journal of Pediatrics, 1983
- Intraventricular hemorrhage following volume expansion after hypovolemic hypotension in the newborn beagleThe Journal of Pediatrics, 1982
- Moderate, rapidly induced hypertension as a cause of intraventricular hemorrhage in the newborn beagle modelThe Journal of Pediatrics, 1980
- Incidence and evolution of subependymal and intraventricular hemorrhage: A study of infants with birth weights less than 1,500 gmThe Journal of Pediatrics, 1978
- Hémorragies cérébrales intra-ventriculaires chez le prématuré Ie partie: Anatomie et physiopathologieNeonatology, 1964