Long Noncoding RNAs in Development and Regeneration of the Neural Lineage
Open Access
- 1 January 2019
- journal article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Symposia on Quantitative Biology
- Vol. 84, 165-177
- https://doi.org/10.1101/sqb.2019.84.039347
Abstract
Long noncoding RNAs (lncRNAs) are gathering increasing attention toward their roles in different biological systems. In mammals, the richest repertoires of lncRNAs are expressed in the brain and in the testis, and the diversity of lncRNAs in the nervous system is thought to be related to the diversity and the complexity of its cell types. Supporting this notion, many lncRNAs are differentially expressed between different regions of the brain or in particular cell types, and many lncRNAs are dynamically expressed during embryonic or postnatal neurogenesis. Less is known about the functions of these genes, if any, but they are increasingly implicated in diverse processes in health and disease. Here, we review the current knowledge about the roles and importance of lncRNAs in the central and peripheral nervous systems and discuss the specific niches within gene regulatory networks that might be preferentially occupied by lncRNAs.Keywords
This publication has 100 references indexed in Scilit:
- Long non-coding RNAs in Huntington's disease neurodegenerationNeurobiology of Disease, 2012
- Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factorsThe EMBO Journal, 2011
- Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence EvolutionCell, 2011
- Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclassesGenes & Development, 2011
- Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitryNature Neuroscience, 2009
- Sox11 transcription factor modulates peripheral nerve regeneration in adult miceBrain Research, 2009
- Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretaseNature Medicine, 2008
- Specific expression of long noncoding RNAs in the mouse brainProceedings of the National Academy of Sciences of the United States of America, 2008
- SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growthNeuroscience, 2006
- The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivatorGenes & Development, 2006