Overview on Determination of Irbesartan Levels in Pharmaceutical Preparation and Biological Matrices

Abstract

Irbesartan is classified as an angiotensin II receptor antagonist. It is used in the treatment of diseases such as hypertension and diabetic nephropathy. It is available in single and combination forms in the market. Drug quality assurance needs to be done to ensure the quality and safety of drugs, one of the quality assurance that can be done by determining the level of medicine. This review provides an analytical method for determining irbesartan levels is collected from literature in the last ten years (2011-2020) through web sources such as Science Direct, Google Scholar, PubMed, Research Gate, and others with the search keyword ―Analysis of Irbesartan in Pharmaceutical Preparation and Biological Matrices‖ and ―Determination of Irbesartan." The methods reported for the analysis of irbesartan in bulk, pharmaceutical preparations, and biological matrices. The analysis method is used, such as spectrophotometry methods, high-performance liquid chromatography (HPLC), and high-performance thin-layer chromatography (HPTLC). Overall, the most used method is high-performance liquid chromatography because not only to pharmaceutical preparations, this method can also be used for biological matrices samples that require a small amount of sample analysis.