Neurobiology of subtypes of trichotillomania and skin picking disorder
Open Access
- 3 November 2021
- journal article
- research article
- Published by Cambridge University Press (CUP) in CNS Spectrums
- Vol. 28 (1), 98-103
- https://doi.org/10.1017/s109285292100095x
Abstract
BackgroundTrichotillomania (TTM) and skin picking disorder (SPD) are common and often debilitating mental health conditions, grouped under the umbrella term of body-focused repetitive behaviors (BFRBs). Recent clinical subtyping found that there were three distinct subtypes of TTM and two of SPD. Whether these clinical subtypes map on to any unique neurobiological underpinnings, however, remains unknown.MethodsTwo hundred and fifty one adults [193 with a BFRB (85.5% [n = 165] female) and 58 healthy controls (77.6% [n = 45] female)] were recruited from the community for a multicenter between-group comparison using structural neuroimaging. Differences in whole brain structure were compared across the subtypes of BFRBs, controlling for age, sex, scanning site, and intracranial volume.ResultsWhen the subtypes of TTM were compared, low awareness hair pullers demonstrated increased cortical volume in the lateral occipital lobe relative to controls and sensory sensitive pullers. In addition, impulsive/perfectionist hair pullers showed relative decreased volume near the lingual gyrus of the inferior occipital–parietal lobe compared with controls.ConclusionsThese data indicate that the anatomical substrates of particular forms of BFRBs are dissociable, which may have implications for understanding clinical presentations and treatment response.Keywords
Funding Information
- TLC Foundation for Body-Focused Repetitive Behaviors (NA)
This publication has 31 references indexed in Scilit:
- Brain Structural Alterations in Obsessive-Compulsive Disorder Patients with Autogenous and Reactive ObsessionsPLOS ONE, 2013
- Disordered reward processing and functional connectivity in trichotillomania: A pilot studyJournal of Psychiatric Research, 2013
- White Matter Abnormalities in Skin Picking Disorder: A Diffusion Tensor Imaging StudyNeuropsychopharmacology, 2012
- A pilot study of brain activation in children with trichotillomania during a visual-tactile symptom provocation task: A functional magnetic resonance imaging studyProgress in Neuro-Psychopharmacology and Biological Psychiatry, 2010
- Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging studyThe British Journal of Psychiatry, 2008
- Brain activation during implicit sequence learning in individuals with trichotillomaniaPsychiatry Research: Neuroimaging, 2007
- Evidence for Reduced Cerebellar Volumes in TrichotillomaniaBiological Psychiatry, 2007
- Motor Inhibition and Cognitive Flexibility in Obsessive-Compulsive Disorder and TrichotillomaniaAmerican Journal of Psychiatry, 2006
- Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imagingBiological Psychiatry, 1997
- Regional Cerebral Glucose Metabolism of Women With TrichotillomaniaArchives of General Psychiatry, 1991