Human inborn errors of immunity: An expanding universe
- 3 July 2020
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science Immunology
- Vol. 5 (49)
- https://doi.org/10.1126/sciimmunol.abb1662
Abstract
Molecular, cellular, and clinical studies of human inborn errors of immunity have revolutionized our understanding of their pathogenesis, considerably broadened their spectrum of immunological and clinical phenotypes, and enabled successful targeted therapeutic interventions. These studies have also been of great scientific merit, challenging a number of immunological notions initially established in inbred mice while revealing previously unrecognized mechanisms of host defense by leukocytes and other cells and of both innate and adaptive tolerance to self.Keywords
Funding Information
- National Institutes of Health (R01 AI088364)
- National Institutes of Health (R01 NS072381)
- National Institutes of Health (R37AI095983)
- National Institutes of Health (P01AI061093)
- National Institutes of Health (R01AI127564)
- National Institutes of Health (R01AI143810)
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- Rockefeller University
- Institut National de la Santé et de la Recherche Médicale
- National Center for Advancing Translational Sciences (UL1 TR001866)
- French National Research Agency (ANR-10-IAHU-01)
- French National Research Agency (ANR-10-LABX-62-IBEID)
- French Foundation for Medical Research (EQU201903007798)
- Paris University
- National Institutes of Health
- California Institute for Regenerative Medicine
- Stanford SPARK
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