Associations between serum calcium, 25(OH)D level and bone mineral density in adolescents
Open Access
- 10 March 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Advances in Rheumatology
- Vol. 61 (1), 1-9
- https://doi.org/10.1186/s42358-021-00174-8
Abstract
Backgrounds It is important to improve our understanding of the roles of calcium and vitamin D in bone health for preventing osteoporosis. We aimed at exploring the associations between serum calcium, vitamin D level, and bone mineral density (BMD) in adolescents included in the National Health and Nutrition Examination Survey (NHANES) 2001–2006. Methods Weighted multivariate linear regression models were used to estimate the associations of serum calcium, 25(OH)D level with total BMD. Smooth curve fitting was used to explore the potential non-linear relationship. Results A total of 5990 individuals aged between 12 and 19 years were included in this study. The fully-adjusted model showed serum calcium positively correlated with total BMD. However, an inverted U-shaped relationship was found when we performed the smooth curve fitting method, and the inflection point was calculated at 9.6 mg/dL using the two-piecewise linear regression model. In contrast, there was a positive correlation between serum 25(OH)D and total BMD after adjusting for potential confounders. Conclusions The present study revealed a positive correlation between serum 25(OH)D level and total BMD, and an inverted U-shaped relationship between serum calcium and total BMD.Keywords
This publication has 34 references indexed in Scilit:
- Mapping low intake of micronutrients across EuropeBritish Journal of Nutrition, 2013
- Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone massJournal of Bone and Mineral Research, 2011
- Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderlyBone, 2010
- Nutrient intakes related to osteoporotic fractures in men and women – The Brazilian Osteoporosis Study (BRAZOS)Nutrition Journal, 2009
- Vitamin D DeficiencyThe New England Journal of Medicine, 2007
- Two year comparison of sevelamer and calcium carbonate effects on cardiovascular calcification and bone densityNephrology Dialysis Transplantation, 2005
- Decrease in Thoracic Vertebral Bone Attenuation With Calcium-Based Phosphate Binders in HemodialysisJournal of Bone and Mineral Research, 2005
- Positive association between 25-hydroxy vitamin d levels and bone mineral density: a population-based study of younger and older adultsThe American Journal of Medicine, 2004
- Osteoporosis in Childhood: Bone Density of Children in Health and DiseaseJournal of Pediatric Endocrinology and Metabolism, 2001
- More Broken Bones: A 4-Year Double Cohort Study of Young Girls With and Without Distal Forearm FracturesJournal of Bone and Mineral Research, 2000