Disposal of wastewater and other effluents into water bodies from activities around water bodies have for long been of major concern and challenge to the environment leading to several infectious diseases. The amount of industrial untreated solid wastes from companies, wastewater from car washing activities, open drainages and agricultural runoffs located close to Elechi creek constitutes the wastewater effluents received by the creek thus resulting in the imbalance of the ecosystem. The study was therefore aimed at determining the microbiology of water quality at different stations of the Elechi creek. Surface water, wastewater and sediment samples were collected during a seven month period and analysed using standard microbiological procedures. Results obtained revealed that the average microbial counts ranged as follows: Total Heterotrophic bacteria 1.12±0.13x108 to 1.28±0.09x108 cfu/ml, Total coliform count; 6.4±0.21 to 7.8±0.13 cfu/ml, Total Staphylococcus Count; 6.9±0.06 to 7.9±0.08 cfu/ml, Total Shigella count; 7.9±0.11 to 8.5±0.14 cfu/ml, Total Salmonella Count; 5.4±0.13 to 7.9±0.08 cfu/ml, Total Vibrio Count; 5.9±0.13 to 7.4±0.09 cfu/ml, and Total Pseudomonad Count; 2.5±0.08 to 4.8 ±0.10 cfu/ml, in surface water, Total Heterotrophic bacteria 1.02±0.08 x108 cfu/ml to 2.68±0.08 x108 cfu/ml, Total coliform count; 4.4±0.10a to 4.9±0.11a cfu/ml, Total Staphylococcus Count;4.7±0.10 to 5.9±0.12 cfu/ml, Total Shigella count; 4.0±0.08 to 4.8±0.11 cfu/ml, Total Salmonella Count; 3.2±0.16 to 4.6±0.08 cfu/ml, Total Vibrio Count; 2.0±0.15 to 4.8±0.11 cfu/ml, and Total Pseudomonad Count2.7±0.13 to 3.9±0.09cfu/ml, in wastewater and Total Heterotrophic bacteria 2.16±0.07 x109 cfu/g to 2.24±0.09 x109 cfu/g, Total coliform count; 1.01±0.13 to 1.36±0.06b cfu/g, Total Staphylococcus Count; 6.8±0.11 to 9.1±0.08 cfu/g, Total Shigella count; 4.0±0.09 to 6.5±0.06 cfu/ml, Total Salmonella Count; 4.1±0.11 to 9.7±0.12 cfu/g, Total Vibrio Count; 6.8±0.10 to 9.5±0.09 cfu/g, and Total Pseudomonad Count; 4.0±0.16 to 5.9±0.07 cfu/g, in sediment samples. Bacterial isolates belonging to the genera Bacillus, Staphylococcus, Enterococcus, Pseudomonas, Proteus, Klebsiella, Providencia, Escherichia coli, Salmonella, Shigella, Vibrio and Enterobacter were isolated and identified. The occurrences of these bacterial isolates as potential pathogens could cause poor water quality through fouling and render the water for various uses and may pose a public health threat to our water resources. Adherence to good hygienic practices and proper treatment of wastewater before discharge into the environment should be encouraged to minimize the spread of infectious diseases and fouling of water bodies. This may also affect the aquatic life in such ecosystems.