Mucormycosis is an angio-invasive infection that occurs due to the fungi mucorales. It is a rare disease but increasingly recognized in immuno-compromised patients. It can be categorized into rhino-orbitocerebral, pulmonary, cutaneous, gastrointestinal, disseminated, and miscellaneous types. The main aim and purpose of this review related to overview and Etiopathogenesis of Mucormycosis, clinical manifestations, recent advances in diagnostic and treatment methods and its Homoeopathic approach.