Zygophyllum album aqueous extract reduces glycemia and ameliorates lipid profile and oxidative damage in hypercholesterolemic-diabetic rats
- 11 February 2019
- journal article
- research article
- Published by Emerald in Nutrition & Food Science
- Vol. 49 (1), 141-157
- https://doi.org/10.1108/nfs-03-2018-0078
Abstract
Purpose This paper aims to study the effects of Zygophyllum album (Za) (Z. album) in hypercholesterolemic-diabetic rats. Design/methodology/approach Male Wistar rats (n = 36) weighing 200 10 g, consumed an experimental diet containing 20 per cent casein were divided into three groups (n = 12). The first group consumed the diet enriched with 1 per cent cholesterol (CH), the second group is rendered diabetic by intraperitoneal injection of streptozotocin (STZ) (35 mg/kg body weight) (D) (DM). The third group is hypercholesterolemic and STZ-induced diabetic (CH-DM); each group was subdivided into two groups (n = 6), non-treated groups (CH, DM and CH-DM) and treated groups supplemented with 1 per cent Z. album lyophilized aqueous extract (CH-Z, DM-Z and CH-DM-Z). Findings In CH-DM group, Z. album decreases glycemia (-15 per cent) and inversely increases insulinemia (+28 per cent) and Homeostasis Model Assessment of Insulin Resistance (+19 per cent). In liver, total cholesterol (TC) and triacyglycerols (TAG) levels were reduced by -57 per cent and -29 per cent, respectively. In plasma, TC concentration was increased by +20 per cent, whereas those of TAG level were lowered by -56 per cent. Lecithin cholesterol acyl transferase and paraoxonase 1 activities were raised by +45 and +59 per cent, respectively. Inversely, thiobarbituric acid reactive substance levels were lowered significantly in liver, heart, kidney and adipose tissue (p < 0.05). Superoxide dismutase activity was enhanced in liver (+54 per cent), heart (+36 per cent), kidney (+45 per cent) and adipose tissue (59 per cent). Liver glutathione peroxidase (GSH-Px) activity was enhanced by +38 per cent and heart activities of GSH-Px, and glutathione reductase (GSSH-Red) were increased by +25 and +18 per cent. In kidney, GSH-Px activity was reduced by -26 per cent; in reverse, GSSH-Red activity was increased by +14 per cent. In adipose tissue, GSH-Px and GSSH-Red activities were augmented by +35 and +15 per cent. Originality/value These results suggest that Z. album aqueous extract has antihyperglycemic and antihyperlipemic actions. Also, Z. album protects against tissue oxidative damage; therefore, it can help to prevent cardiovascular complications of diabetes combined with hypercholesterolemia.Keywords
This publication has 45 references indexed in Scilit:
- Inhibition of carbohydrate and lipid digestive enzymes activities by Zygophyllum album extracts: effect on blood and pancreas inflammatory biomarkers in alloxan-induced diabetic ratsJournal of Physiology and Biochemistry, 2013
- Efficacy of Evolvulus alsinoides (L.) L. on insulin and antioxidants activity in pancreas of streptozotocin induced diabetic ratsJournal of Diabetes & Metabolic Disorders, 2013
- Diabetes mellitus: An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activityAsian Pacific Journal of Tropical Biomedicine, 2012
- Liuwei Dihuang Lowers Body Weight and Improves Insulin and Leptin Sensitivity in Obese RatsEvidence-Based Complementary and Alternative Medicine, 2012
- Inhibitory Activities ofZygophyllum album: A Natural Weight-Lowering Plant on Key Enzymes in High-Fat Diet-Fed RatsEvidence-Based Complementary and Alternative Medicine, 2012
- Alleviating the burden of diabetic nephropathyNature Reviews Nephrology, 2011
- The mechanism of dietary cholesterol effects on lipids metabolism in ratsLipids in Health and Disease, 2010
- Anti-Diabetic Activity of Aqueous Extract of Monascus purpureus Fermented Rice in High Cholesterol Diet Fed-Streptozotocin-Induced Diabetic RatsAsian Journal of Scientific Research, 2009
- The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat ModelExperimental Diabetes Research, 2008
- Animal models of diabetes mellitusDiabetic Medicine, 2005