Background and Aim: Sevoflurane and Desflurane are the inhalation anaesthetic agents are the most frequently used drugs for giving general anaesthesia to the patients. The purpose of this study was to evaluate desflurane and compare it with sevoflurane in terms of intraoperative haemodynamic stability and any other side effects noted in elective laparoscopic surgeries. Methods: A prospective randomized controlled study was conducted over 60 ASA I-III patients posted for laparoscopic surgeries. Basal HR, SBP, DBP, Oxygen saturation were noted. Patients were pre-medicated and induced and were maintained on inhalation agents according to the group allocated. Haemodynamic parameters were recorded at 1, 5, 10 minutes after intubation and then every 15 minutes throughout the operative period. After extubation, patients were monitored and treated for complications such as hypo/ hypertension, tachy/bradycardia. Incidence of cough, nausea, vomiting, sore throat, laryngospasm, blood on device, lip and dental trauma were noted. Haemodynamic parameters and side effects were compared amongst both groups. Results: We observed no statistically significant difference in heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure between the groups at any time interval (p>0.05). All the patients were observed for side effects and adverse effects during perioperative period. None of the patients in either group had side effects like hypotension, bradycardia, nausea, vomiting, arrhythmias, shivering, cough, sore throat. Conclusion: Desflurane and sevoflurane when compared as a maintainance agent during laparoscopic surgery were comparable with respect to intraoperative haemodynamics parameters and perioperative complications.