Plants as Modulators of Melanogenesis: Role of Extracts, Pure Compounds and Patented Compositions in Therapy of Pigmentation Disorders
Open Access
- 26 November 2022
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 23 (23), 14787
- https://doi.org/10.3390/ijms232314787
Abstract
The kingdom of plants as a “green biofabric” of valuable bioactive molecules has long been used in many ailments. Currently, extracts and pure compounds of plant origin are used to aid in pigmentation skin problems by influencing the process of melanogenesis. Melanin is a very important pigment that protects human skin against ultraviolet radiation and oxidative stress. It is produced by a complex process called melanogenesis. However, disturbances in the melanogenesis mechanism may increase or decrease the level of melanin and generate essential skin problems, such as hyperpigmentation and hypopigmentation. Accordingly, inhibitors or activators of pigment formation are desirable for medical and cosmetic industry. Such properties may be exhibited by molecules of plant origin. Therefore, that literature review presents reports on plant extracts, pure compounds and compositions that may modulate melanin production in living organisms. The potential of plants in the therapy of pigmentation disorders has been highlighted.This publication has 131 references indexed in Scilit:
- Mechanisms regulating melanogenesis*Anais Brasileiros de Dermatologia, 2013
- Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase ExpressionEvidence-Based Complementary and Alternative Medicine, 2013
- Whitening efficacy of plant extracts including Hippophae rhamnoides and Cassia fistula extracts on the skin of Asian patients with melasmaAdvances in Dermatology and Allergology, 2013
- Medicinal plants used in treatment of inflammatory skin diseasesAdvances in Dermatology and Allergology, 2013
- Inhibitory effects of Cyrtomium fortunei J. Smith root extract on melanogenesisPharmacognosy Magazine, 2013
- Milestones in Melanocytes/MelanogenesisJournal of Investigative Dermatology, 2011
- C-KIT Signaling Depends on Microphthalmia-Associated Transcription Factor for Effects on Cell ProliferationPLOS ONE, 2011
- Targeting the MAPK pathway in melanoma: Why some approaches succeed and other failBiochemical Pharmacology, 2010
- The Protective Role of Melanin Against UV Damage in Human Skin†Photochemistry and Photobiology, 2007
- The Microphthalmia-Associated Transcription Factor Mitf Interacts with β-Catenin To Determine Target Gene ExpressionMolecular and Cellular Biology, 2006