Biological Dose Comparison between a Fixed RBE and a Variable RBE in SFO and MFO IMPT with Various Multi-Beams for Brain Cancer
Open Access
- 1 January 2019
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in International Journal of Medical Physics, Clinical Engineering and Radiation Oncology
- Vol. 08 (01), 32-45
- https://doi.org/10.4236/ijmpcero.2019.81004
Abstract
IMPT plans with various multi-angle beams were planned by the Varian Eclipse treatment planning system for one case of brain cancer. Dose distributions for each plan, along with the associated linear energy transfer distributions, were recomputed using an in-house fast Monte Carlo dose calculator with a FRBE of 1.1 or with a previously published VRBE model. We then compared dosimetric parameters obtained by the VRBE with those obtained by the FRBE. Biological doses obtained by the VRBE for the clinical target volume in all plans were 1% - 2% larger than those obtained by the FRBE. The minimum dose obtained by the VRBE for the right optic nerve in the MFO IMPT with 4 fields was 70% larger than that obtained by the FRBE, but the difference was only 18.1 cGy (RBE). The difference in maximum dose for the right optic nerve in the MFO IMPT with 5 fields was less than 10.4%, but the difference was 131.8 cGy (RBE). The mean difference in maximum dose was less than 2% for all other organs at risk. We found that biological dose with the FRBE had any dose errors in IMPT with various multi-angle beams.Keywords
This publication has 32 references indexed in Scilit:
- Risk of radiogenic second cancers following volumetric modulated arc therapy and proton arc therapy for prostate cancerPhysics in Medicine & Biology, 2012
- Charged particles in radiotherapy: A 5-year update of a systematic reviewRadiotherapy and Oncology, 2012
- Application of Constant vs. Variable Relative Biological Effectiveness in Treatment Planning of Intensity-Modulated Proton TherapyEndocrine, 2011
- Improved dose-calculation accuracy in proton treatment planning using a simplified Monte Carlo method verified with three-dimensional measurements in an anthropomorphic phantomPhysics in Medicine & Biology, 2010
- Monte Carlo fast dose calculator for proton radiotherapy: application to a voxelized geometry representing a patient with prostate cancerPhysics in Medicine & Biology, 2008
- A systematic literature review of the clinical and cost-effectiveness of hadron therapy in cancerRadiotherapy and Oncology, 2007
- Proton therapy – A systematic review of clinical effectivenessRadiotherapy and Oncology, 2007
- Simplified Monte Carlo Dose Calculation for Therapeutic Proton BeamsJapanese Journal of Applied Physics, 2002
- A pencil beam algorithm for proton dose calculationsPhysics in Medicine & Biology, 1996
- Radiation therapy oncology group: Radiosurgery quality assurance guidelinesEndocrine, 1993