Insertion of Alkylidene Carbenes into B–H Bonds
- 25 November 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 142 (50), 20924-20929
- https://doi.org/10.1021/jacs.0c09596
Abstract
We have developed a protocol for insertion of alkylidene carbenes into the B–H bonds of amine–borane adducts, enabling, for the first time, the construction of C(sp2)–B bonds by means of carbene-insertion reactions. Various acyclic and cyclic alkenyl borane–amine adducts were prepared from readily accessible starting materials in good to high yields and were subsequently subjected to a diverse array of functional group transformations. The unprecedented spiro B–N heterocycles prepared in this study have potential utility as building blocks for the synthesis of pharmaceuticals. Preliminary mechanistic studies suggest that insertion of the alkylidene carbenes into the B–H bonds of the amine–borane adducts proceeds via a concerted process involving a three-membered-ring transition state.Keywords
Funding Information
- State Administration of Foreign Experts Affairs (B06005)
- Ministry of Education of the People's Republic of China (B06005)
- National Natural Science Foundation of China (21532003, 21625204, 21790332, 21971119)
- Guangdong Province (2020B010188001)
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