Resistance Exercise-Induced Hypertrophy: A Potential Role for Rapamycin-Insensitive mTOR
- 12 March 2019
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Exercise and Sport Sciences Reviews
- Vol. 47 (3), 188-194
- https://doi.org/10.1249/jes.0000000000000189
Abstract
The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.Keywords
This publication has 54 references indexed in Scilit:
- mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and RapamycinScience, 2013
- Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophySkeletal Muscle, 2013
- mTOR Signaling in Growth Control and DiseaseCell, 2012
- The role of skeletal muscle mTOR in the regulation of mechanical load‐induced growthJournal Of Physiology-London, 2011
- Structure of the Human mTOR Complex I and Its Implications for Rapamycin InhibitionMolecular Cell, 2010
- Rapamycin administration in humans blocks the contraction‐induced increase in skeletal muscle protein synthesisJournal Of Physiology-London, 2009
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1Online Journal of Public Health Informatics, 2009
- The TSC-mTOR Pathway Mediates Translational Activation of TOP mRNAs by Insulin Largely in a Raptor- or Rictor-Independent MannerMolecular and Cellular Biology, 2009
- mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth MachineryCell, 2002
- Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.The Journal of Antibiotics, 1975