A malignant glomus tumor in the nasal cavity responding to radiation therapy
- 4 May 2022
- journal article
- research article
- Published by Medknow in Journal of Cancer Research and Therapeutics
- Vol. 19 (5), 1436-1438
- https://doi.org/10.4103/jcrt.jcrt_1394_21
Abstract
Malignant glomus tumors of the head and neck are extremely rare, and to our knowledge, a response to high-dose radiation has not been described previously. We report one case in an 80-year-old woman with right nasal cavity mass. Histological examination revealed sheets of atypical round glomus cells. The presence of increased mitotic activity (25 per 10 high-power fields), cellular atypism, and tumor necrosis suggested malignancy. The smooth muscle actin, vimentin, and h-caldesmon immunohistochemistry stains the tumor cells. Two cycles of doxorubicin and cyclophosphamide chemotherapy were done and the tumor size was slightly increased. Salvage radiation therapy (RT) was delivered to the primary mass over 4 weeks (50 Gy in 20 fractions) and leading to nearly complete regression of tumor. Additional investigations are warranted so that we may determine the usefulness of RT in the management of this rare tumor.This publication has 8 references indexed in Scilit:
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