Stroke Due to Hypercoagulable State Can Mimic Multiple Sclerosis: A Case Report
Open Access
- 1 January 2017
- journal article
- Published by Scientific Research Publishing, Inc. in World Journal of Neuroscience
- Vol. 07 (03), 267-274
- https://doi.org/10.4236/wjns.2017.73022
Abstract
Introduction: Stroke is the second major cause of mortality worldwide and in several cases, and it may lead to disability. Factor V Leiden is a common genetic thrombophilia, which causes activated protein C (APC) resistance. Hyperhomocysteinemia and factor V Leiden deficiency, two independent coagulopathy factors, can lead to venous and arterial infarctions in multiple small and large arteries and veins anywhere in the body. Case Report: Here, we report a unique case in which both hyperhomocysteinemia and factor V Leiden deficiency are documented together with MTHFR (C677T) (Methylene Tetra Hydro Folate Reductase) gene polymorphism and activated protein C resistance respectively. Conclusion: More interestingly, the mode of presentation in this case highly resembled that of progressive multiple sclerosis; all signs and symptoms slowly progressed without any systemic signs at first few years. Further studies needed to assess current outcomes.Keywords
This publication has 1 reference indexed in Scilit:
- Factor V Leiden, prothrombin G20210A, and methylene tetrahydrofolate reductase mutations and stillbirth: the Stillbirth Collaborative Research NetworkAmerican Journal of Obstetrics and Gynecology, 2016