Flowable placental connective tissue matrices for tendon repair: A review
- 30 September 2022
- journal article
- review article
- Published by Peertechz Publications Private Limited in Journal of Biology and Medicine
- Vol. 6 (1), 010-020
- https://doi.org/10.17352/jbm.000030
Abstract
Tendon injuries are associated with considerable pain and disability. Owing to the hypovascularity and hypocellularity of the tissue, natural tendon healing is slow and ineffective. Traditional conservative and surgical treatment options fail to address the underlying pathology. As a result, the healed tendon is mechanically incompetent and prone to degeneration and rupture. Therefore, new biological methods have been suggested to enhance tendon repair and regeneration. Flowable Placental Connective Tissue Matrices (FP-CTMs) represent a promising means to promote tendon healing. Like non-flowable placental scaffolds, FP-CTMs possess the innate healing properties of the placenta and provide structural and biochemical extracellular matrix components. Unlike their non-flowable counterparts, FP-CTMs have the added benefits of minimal invasiveness and the capacity to fill irregular spaces. FP-CTMs can enhance tendon repair by providing a three-dimensional extracellular matrix for cellular attachment and proliferation while decreasing inflammation and limiting adhesion formation. The present report reviews tendon biology, pathology, healing, and current treatment modalities, followed by a comprehensive literature review, evaluating the clinical application of FP-CTMs for tendon repair. Recent research suggests that the use of FP-CTMs in tendon repair is safe and efficacious and further indicates that FP-CTMs can modulate the tendon repair environment and improve clinical outcomes. However, the existing clinical evidence is limited to retrospective case series with no control group. Therefore, additional work must be performed to better understand the clinical applications and therapeutic benefits of FP-CTM in tendon repair compared with conventional treatments.Keywords
This publication has 75 references indexed in Scilit:
- Amniotic membrane: from structure and functions to clinical applicationsCell and tissue research, 2012
- What We Should Know Before Using Tissue Engineering Techniques to Repair Injured Tendons: A Developmental Biology PerspectiveTissue Engineering, Part B: Reviews, 2011
- Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: a systematic review of randomised controlled trialsThe Lancet, 2010
- Adverse effects of extra-articular corticosteroid injections: a systematic reviewBMC Musculoskeletal Disorders, 2010
- Efficacy and safety of steroid injections for shoulder and elbow tendonitis: a meta-analysis of randomised controlled trialsAnnals Of The Rheumatic Diseases, 2008
- Tendon tissue engineering using scaffold enhancing strategiesTrends in Biotechnology, 2008
- Chronic tendon pathology: molecular basis and therapeutic implicationsExpert Reviews in Molecular Medicine, 2005
- Functional Efficacy of Tendon Repair ProcessesAnnual Review of Biomedical Engineering, 2004
- Characterisation of proteoglycans and their catabolic products in tendon and explant cultures of tendonMatrix Biology, 2004
- Correlation of cartilage oligomeric matrix protein (COMP) levels in equine tendon with mechanical properties: a proposed role for COMP in determining function‐specific mechanical characteristics of locomotor tendonsEquine Veterinary Journal, 2002