Pathomorphological Changes in Organs of Rabbits with Experimental Colibacillosis

Abstract

The aim of this research was to study pathomorphological alterations in the internal organs of rabbits through experimental reproduction of colibacillosis. The studies were conducted on 10 clinically healthy rabbits at the age of 3 months from a private farm. Animals were infected by intraperitoneal injection of a suspension of a pure culture of Escherichia coli isolated from a sand lizard. The disease of infected rabbits was accompanied by cachexia, dehydration and fever. The pathological process in the organism of infected animals was characterized by the violation of hemodynamics, the protein dystrophy of the parenchyma of liver, kidneys, myocardium and the formation of specific granulomas in the lungs and liver. The edema of reticular tissue and the hyperplasia of lymph nodes were observed in the organs of the immune system. The expressive edema of mucous membrane and submucosa, as well as alterative and necrotic processes were detected in the intestine.