Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine
Open Access
- 30 June 2017
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 8 (2), 179-182
- https://doi.org/10.5155/eurjchem.8.2.179-182.1567
Abstract
Dibenzoazepine represents an important class of heterocycles, exhibiting potent antidepressant and anticonvulsant activities. Beside, various modifications on this nucleus, amide analogs at N-5 position showed potent antidepressant activities. A previously reported method for the synthesis of benzamide analogs of dibenzoazepine use hazardous and toxic solvents. Herein, we report a new, efficient and solvent-free green method for the synthesis of dibenzoazepine benzamides (6-21).Keywords
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