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Prognostic value of neutrophil gelatinase-associated lipocalin and cystatin C in patients with heart failure and previous myocardial infarction

N. V. Kompanets, Yu. V. Shchukin, L. V. Limareva, M. V. Komarova
Published: 17 February 2021
Russian Journal of Cardiology , Volume 26; doi:10.15829/1560-4071-2021-4126

Abstract: Aim. To study the prognostic value of neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2) and cystatin C in patients with heart failure (HF) and myocardial infarction (MI). Material and methods. Baseline plasma concentrations of NGAL and cystatin C were measured in 119 participants (median age, 50-61 years; men, 101) with HF and primary MI (4-6 weeks old) who underwent percutaneous coronary intervention in the acute period. Adverse cardiovascular events within 1 year were considered as the endpoint. Results. Patients with elevated NGAL levels were significantly more likely to have adverse events (p Conclusion. Increased NGAL levels is a predictor of unfavorable clinical outcome in patients with HF and previous MI.
Keywords: neutrophil / prognostic / infarction / CYSTATIN / myocardial / NGAL / Lipocalin / gelatinase

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