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COVID-19 Critical Illness: A Data-Driven Review

Jennifer C. Ginestra, Oscar J.L. Mitchell, George L. Anesi, Jason D. Christie
Published: 14 September 2021

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges in critical care medicine, including extreme demand for intensive care unit (ICU) resources and rapidly evolving understanding of a novel disease. Up to one-third of hospitalized patients with COVID-19 experience critical illness. The most common form of organ failure in COVID-19 critical illness is acute hypoxemic respiratory failure, which clinically presents as acute respiratory distress syndrome (ARDS) in three-quarters of ICU patients. Noninvasive respiratory support modalities are being used with increasing frequency given their potential to reduce the need for intubation. Determining optimal patient selection for and timing of intubation remains a challenge. Management of mechanically ventilated patients with COVID-19 largely mirrors that of non-COVID-19 ARDS. Organ failure is common and portends a poor prognosis. Mortality rates have improved over the course of the pandemic, likely owing to increasing disease familiarity, data-driven pharmacologics, and improved adherence to evidence-based critical care. Expected final online publication date for the Annual Review of Medicine, Volume 73 is January 2022. Please see for revised estimates.
Keywords: COVID / pandemic / intubation / respiratory / extreme / optimal / critical care / Data Driven / ARDS

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