Background: Neutropenia, usually defined as an absolute neutrophil count below 1.5 × 109/L, encompasses a wide range of diagnoses, from normal variants to life-threatening acquired and congenital disorders. The present study evaluated cases of neutropenia and fever in children. Materials & Methods: 104 children confirmed case of fever and neutropenia of both genders Were studied. Results: Age group 10-12 years had 14 boys and 8 girls, 12-14 years had 20 boys and 10 girls and 14-16 years had 30 boys and 12 girls. The main cause of neutropenia was bacterial in 54, viral in 20, fungal in 15, drugs in10 and autoimmune in 5 cases. The difference was significant (P<0.05). Out of 104 patients, 98 survived and 6 died. The difference was significant (P<0.05). Conclusion: Authors found that maximum cases were seen in boys and age group 14-16 years.