Coronavirus pleomorphism
- 1 June 2022
- journal article
- research article
- Published by AIP Publishing in Physics of Fluids
- Vol. 34 (6)
- https://doi.org/10.1063/5.0094771
Abstract
The coronavirus is always idealized as a spherical capsid with radially protruding spikes. However, histologically, in the tissues of infected patients, capsids in cross section are elliptical, and only sometimes spherical [Neuman et al., "Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy, " J Virol, 80, 7918 (2006)]. This capsid ellipticity implies that coronaviruses are oblate or prolate or both. We call this diversity of shapes, pleomorphism. Recently, the rotational diffusivity of the spherical coronavirus in suspension was calculated, from first principles, using general rigid bead-rod theory [Kanso et al., "Coronavirus rotational diffusivity, " Phys Fluids 32, 113101 (2020)]. We did so by beading the spherical capsid and then also by replacing each of its bulbous spikes with a single bead. In this paper, we use energy minimization for the spreading of the spikes, charged identically, over the oblate or prolate capsids. We use general rigid bead-rod theory to explore the role of such coronavirus cross-sectional ellipticity on its rotational diffusivity, the transport property around which its cell attachment revolves. We learn that coronavirus ellipticity drastically decreases its rotational diffusivity, be it oblate or prolate. Published under an exclusive license by AIP Publishing.Keywords
This publication has 30 references indexed in Scilit:
- Who conceived the “complex viscosity”?Rheologica Acta, 2012
- Erratum: Official Nomenclature of The Society of Rheology: −η″Journal of Rheology, 2011
- A structural analysis of M protein in coronavirus assembly and morphologyJournal of Structural Biology, 2011
- Defect motifs for spherical topologiesPhysical Review B, 2009
- Structure and dynamics of spherical crystals characterized for the Thomson problemPhysical Review B, 2006
- Supramolecular Architecture of Severe Acute Respiratory Syndrome Coronavirus Revealed by Electron CryomicroscopyJournal of Virology, 2006
- Projected Hessian Updating Algorithms for Nonlinearly Constrained OptimizationSIAM Journal on Numerical Analysis, 1985
- Kinetic theory and rheology of bead—rod models for macromolecular solutions. II. Linear unsteady flow propertiesThe Journal of Chemical Physics, 1974
- The rheology of a suspension of nearly spherical particles subject to Brownian rotationsJournal of Fluid Mechanics, 1972
- XXIV. On the structure of the atom: an investigation of the stability and periods of oscillation of a number of corpuscles arranged at equal intervals around the circumference of a circle; with application of the results to the theory of atomic structureThe London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science, 1904