Effect of exogenous fatty acids on growth, membrane fluidity, and phospholipid fatty acid composition in yeast
- 1 January 1981
- journal article
- research article
- Published by Wiley in Journal of Supramolecular Structure and Cellular Biochemistry
- Vol. 15 (2), 119-128
- https://doi.org/10.1002/jsscb.1981.380150203
Abstract
The growth response of a double-mutant fatty acid auxotroph of yeast Saccharomyces cerevisiae to exogenous saturated fatty acids of a homologous series from 12:0 to 16:0, each supplied with oleate, linoleate, linolenate, or cis-Δ11- eicosenoate, cannot be explained in terms of the efficiency of incorporation of the fatty acids into phospholipids or alteration of membrane fluidity. There is, however, a negative correlation between growth and levels of 12:0 plus 13:0 in phospholipids, as well as a positive correlation between growth and levels of 14:0, 1 5:0, and 1 6:0. We, therefore, conclude that the predominant factor in these phospholipid fatty acyl chain modifications is maintenance of an optimal concentration of C14:0 through C16:0 in phospholipids of this organism.Keywords
This publication has 27 references indexed in Scilit:
- Lipid‐protein interactions in membranes: Effect of lipid composition on mobility of spin‐labeled cysteine residues in yeast plasma membraneJournal of Supramolecular Structure, 1979
- Functional properties of biological membranes: A physical-chemical approachProgress in Biophysics and Molecular Biology, 1976
- Clusters in lipid bilayers and the interpretation of thermal effects in biological membranesBiochemistry, 1974
- Effect of chain length on the stability of lecithin bilayersBiochemical and Biophysical Research Communications, 1973
- Biochemistry of Bacterial MembranesAnnual Review of Biochemistry, 1973
- Lipid composition of Saccharomyces cerevisiae as influenced by growth temperatureBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
- Fatty‐Acid Elongation in a Mutant of Saccharomyces cerevisiae Deficient in Fatty‐Acid SynthetaseJBIC Journal of Biological Inorganic Chemistry, 1972
- Membrane properties of saturated fatty acid mutants of yeast revealed by spin labelsChemistry and Physics of Lipids, 1971
- A Saccharomyces cerevisiae Mutant Defective in Saturated Fatty Acid BiosynthesisProceedings of the National Academy of Sciences of the United States of America, 1970
- THE BIOGENESIS OF MITOCHONDRIAThe Journal of cell biology, 1968