Excretion rates of 1,5-anhydro-D-glucitol, uric acid and microalbuminuria as glycemic control indexes in patients with type 2 diabetes
Open Access
- 10 March 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 7 (1), srep44291
- https://doi.org/10.1038/srep44291
Abstract
1,5-anhydroglucitol (1,5-AG), uric acid and urinary proteins are excreted into the urine with increasing glucosuria. In the present retrospective study we analyzed whether these factors could be used as indicators for type 2 diabetes mellitus (T2DM) glucose control in 6,766 (T2DM) patients. There were 3,988 cases (58.9%) with HbA1c ≤ 6.5%, 853 cases (12.61%) with HbA1c levels ranging from 6.5% to 7% and 1,925 cases (28.5%) with HbA1c > 7%. HbA1c percentages were correlated with age, MA and 1,5-AG serum concentrations (P < 0.001). The serum uric acid concentration (P < 0.001) was significantly lower in elevated MA (P < 0.001) and 24-hour urinary protein (P = 0.024) patients. Hb1Ac percentages (P < 0.001) were significantly enhanced in patients with 1,5-AG serum concentrations ≤10 mg/L compared to >10 mg/L. With a derived receiver operating characteristic (ROC) curve, a 1,5-AG cut-off value of 11.55 mg/L for hyperglycemia could be diagnosed with a specificity of 71.2 (69.7–72.6) and a sensitivity of 75.3 (73.6–76.9). The serum 1,5-AG concentration is a marker for hyperglycemia and may be particularly useful as an indicator for short-term glycemic excursions in order to improve treatments in T2DM patients.This publication has 29 references indexed in Scilit:
- Association between hyperuricemia, prediabetes, and prehypertension in the Croatian adult population - a cross-sectional studyBMC Cardiovascular Disorders, 2012
- Serum 1,5-Anhydroglucitol Concentrations Are a Reliable Index of Glycemic Control in Type 2 Diabetes With Mild or Moderate Renal DysfunctionDiabetes Care, 2012
- The glycation of albumin: Structural and functional impactsBiochimie, 2011
- Association between Serum Uric Acid Levels and Diabetes MellitusInternational Journal of Endocrinology, 2011
- 1,5-Anhydroglucitol and Postprandial Hyperglycemia as Measured by Continuous Glucose Monitoring System in Moderately Controlled Patients With DiabetesDiabetes Care, 2006
- Earlier detection of microalbuminuria in diabetic patients using a new urinary albumin assayKidney International, 2004
- Microalbumin measurement alone or calculation of the albumin/creatinine ratio for the screening of hypertension patients?Nephrology Dialysis Transplantation, 2002
- Kinetics of HbA1c, Glycated Albumin, and Fructosamine and Analysis of Their Weight Functions Against Preceding Plasma Glucose LevelDiabetes Care, 1995
- Plasma 1,5-Anhydroglucitol Concentration in Patients with End-Stage Renal Disease with and without Diabetes MellitusNephron, 1992
- Diabetes, prediabetes and uricaemiaDiabetologia, 1976