Study of nitrazepam interaction with alcohol: an ultrasonic and physiochemical investigation

Abstract

The intermolecular interaction between the constituent components of liquid mixtures can be revealed by ultrasonic analysis. In the present study, interaction of nitrazepam with methyl alcohol has been studied and presented using ultrasonic tools. The investigation involves calculation of ultrasonic velocity (υ), density (ρ), viscosity (η), and the associated derived parameters. The specific acoustic impedance (Z), isentropic compressibility (β), relaxation time (τ), intermolecular free length (L_f), and solvation number (S_n) are calculated to reveal the interaction information. The solvent–solvent and solute–solvent interaction between nitrazepam and alcohol molecules is considered. To see the impact of nitrazepam with alcohol in an ordinary day to day scenario, the investigation was carried out under normal temperature (303–313 K) and pressure conditions. The results indicate increased molecule association of nitrazepam in the presence of alcohol. This study suggests the presence of a synergistic depressants effect when nitrazepam is used with alcohol.