Prognosis after neoadjuvant chemoradiation or chemotherapy for locally advanced gastro-oesophageal junctional adenocarcinoma
- 28 May 2021
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 108 (11), 1332-1340
- https://doi.org/10.1093/bjs/znab228
Abstract
Treating advanced cancer of the gastro-oesophageal junction (GOJ) poses a challenge given its location in the distal oesophagus and proximal stomach, and whether it should be treated as oesophageal or gastric cancer. Given the indistinct location, it is unclear whether GOJ cancer should be treated with neoadjuvant chemoradiation, which is the treatment of choice for advanced oesophageal cancers, or perioperative chemotherapy, which is the treatment of choice for advanced gastric cancers. Few studies have addressed treatment options specifically for GOJ cancers. This study investigated whether there was a difference in survival between patients with GOJ cancer who were treated with chemoradiation versus chemotherapy.Funding Information
- National Cancer Institute
- National Institutes of Health (P30 CA008748)
This publication has 33 references indexed in Scilit:
- Development and Assessment of Memorial Sloan Kettering Cancer Center’s Surgical Secondary Events Grading SystemAnnals of Surgical Oncology, 2014
- Outcomes of induction chemotherapy followed by chemoradiation using intensity-modulated radiation therapy for esophageal adenocarcinomaDiseases of the Esophagus, 2013
- Preoperative Chemoradiotherapy for Esophageal or Junctional CancerThe New England Journal of Medicine, 2012
- Perioperative Chemotherapy Compared With Surgery Alone for Resectable Gastroesophageal Adenocarcinoma: An FNCLCC and FFCD Multicenter Phase III TrialJournal of Clinical Oncology, 2011
- Is concurrent radiation therapy required in patients receiving preoperative chemotherapy for adenocarcinoma of the oesophagus? A randomised phase II trialEuropean Journal of Cancer, 2011
- Long-Term Results of a Randomized Trial of Surgery With or Without Preoperative Chemotherapy in Esophageal CancerJournal of Clinical Oncology, 2009
- Phase III Comparison of Preoperative Chemotherapy Compared With Chemoradiotherapy in Patients With Locally Advanced Adenocarcinoma of the Esophagogastric JunctionJournal of Clinical Oncology, 2009
- Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal CancerThe New England Journal of Medicine, 2006
- Chemotherapy Followed by Surgery Compared with Surgery Alone for Localized Esophageal CancerThe New England Journal of Medicine, 1998
- Classification of adenocarcinoma of the oesophagogastric junctionBritish Journal of Surgery, 1998